Is there any way to predict what your day will be like tomorrow? Basically it means there is no way of telling what anti piracy measures nintendo will take.
There is, kind of. It's how Rudolph's Universal patch works, and how the auto patchers work for many of the better flashcarts. But, it's only as good as the patterns are. If the AP is modified then the existing patchers cannot find them.
It is though. The universal patchers attempt to create a fix for AP before the game is released. They just don't always work.
AKAIO has in the past been able to do that. It worked around Pokemon's AP automatically. SCDS2 is supposed to be able to as well, but i haven't seen any examples.