When I try to play Professor Layton and Curious Village and I click the New Game button and the game goes to a black screen and I can't do anything. I had the game working before (~3 months ago). I'm using No$GBA 2.6a with NoZoomer 2.3.0.2 with No sound output and Auto as the save option. Any help would be greatly appreciated.
Try deleting your no$gba.ini file, and load the game again. If that's not working, try using this package. This game should be playable on the latest version of no$gba.
By the way, use the OpenGl renderer on no$gba to fix the graphical glitches on this game, and disable Ex 0 on no$zoomer.