Is reality confined to what is in principle perceptible to the senses?

I suppose the answer would be another question, If a tree falls in a forest, and no one's there, does it make a sound?

http://www.youtube.com/watch?v=vFMqWpfZUSw

However I feel this question and it's answer will change with time.

Why? Well because we invent technology to make things we cannot interact with, detectable by the senses. Something as simplex a man looking through a microscope proves this, does it not?
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I feel that the content of my above post merely repeats the title thereof.

*shrug*

 

are you high?

 

Although Cannabis was intended for use as a psychoactive drug, which is something I could benefit from at present, the detrimental effects would not be in my best interest.