if you emulate gba, then no. only the supercard can do this because it has hardware to do so. but you can buy a slot 2 adapter called ezflash 3 in 1 and play through that (this only works if you have a nds or ndsl)
But DSTWO has got great ROM compatibility, a SNES emulator, GBA emulator and iReader : NOW CHOOSE TIME.
Or if you're totally insane you can get an old SLOT-2 flash card like an M3 perfect or Supercard Slot2 XD Really, tho, the EZ flash is probly the best choice for GBA only. But if you want other stuff too get a DSTWO.