I voted for quagmire. He's awesome. Giggity. if you don't believe me check this video out. http://www.youtube.com/watch?v=Ccvyi3-bqKY&feature=related
Herbert. My second choice would be Glen. Thats for the guys of Family Guy. For girls in Family Guy, i would definitely choose Meg, she might have few to non-existent line, but hey, the girl that voice her is Mila Kunis. Come on, its worth it.
EDIT: Just realized there was meg, meg is the best so unpopular it's a win. Too bad i already voted oh well.